My Christmas Blog 2021 looks at the fluid physiology of nanobubbles. Clinicians are comfortable with solution of gas molecules in aqueous solutions. We measure the partial pressures of vital gases in blood very frequently, and understand that greater pressure means more molecules (of O2, CO2 etc) per unit volume. We can draw diagrams of O2…… Continue reading Nanobubbles
This week I received an email from friend & colleague William (Bill) Muir in the USA. He shared some papers for me to comment on, and they have led me through some very interesting observations about the current state of sciences and their divergence. Time was that medicine and physiology were one and the same;…… Continue reading The Biological/Physical Sciences Divide, and the Age of Unreason
Every now and then, usually when a Renewal bill arrives, I wonder whether it is worth renewing and maybe I should let this web page pass away with dignity. I started teaching the obvious absurdities of biophysical colloid osmotic pressure manipulations (‘therapies’ except that they don’t actually treat anything) about 2010. Then I had my…… Continue reading check out @thomaswoodcock and https://fluidphysiology.org for more info. I just make his stuff understandable for mere mortals like me
Delighted to say the type setter has done her job and you should soon be able to get a more affordable edition of my book from Cambridge Scholars Publishing . I’d like to take this opportunity to Thank CSP for making this project happen. The big publishing companies (we know who they are) have an…… Continue reading Fluid Physiology – the paper back edition is here.
The recent publication by Löffel et al1 concerning the Starling principle reveals some important misunderstandings common amongst clinicians about the science. The Authors confuse the Frank Starling Law (of the heart) with Starling’s principle of fluid exchange, often expressed as the Starling equation which I explain here. Jv is the transendothelial solvent filtration rate, A…… Continue reading Misconceptions about the Starling principle as applied to fluid therapy.
I’m delighted to hear from the Publisher that sales of Fluid Physiology in hardback continue to be strong, and that they feel confident to expand our readership by offering a paperback version at a more affordable price. My hope is that this will enable every prescriber of fluid therapy to have their own copy, or…… Continue reading A big Thankyou to purchasers of the Textbook of Fluid Physiology…
The traditional paradigm of lecture theatre gatherings, authoritative Textbooks, accredited congresses and conferences has rapidly dwindled. Today people are choosing Twitter Experts, non-peer reviewed electronic publications, and on-line Presentations without live interactions. Love it or loathe it, there is no going back. Fake News communications are increasingly succeeding in getting published in previously reputable journals;…… Continue reading Medical Education in a post pandemic world
Ernest Henry Starling CMG FRCP FRS (17 April 1866 – 2 May 1927) was very much a clinical scientist and believed that a bottle of intravenous gooey stuff would save Great War victims of wound shock. Research methodology and ethics was pretty rudimentary in the early twentieth century. He seems to have been unclear on…… Continue reading Happy Birthday Ernest Starling, 155 today.
The Intensive Care Society’s Webinar on Fluids yesterday was Sold Out with record number of delegates and is receiving rave reviews. Ashley Miller’s drawing of the J curve “explains it all as you’ve never seeen it” @PARADicmSHIFT. I reproduce it below. My first attempt at the J curve looked like this in 2012; It makes…… Continue reading Renewed interest in Kinetic diagrams.
The American Journal of Pathology Special edition opens with an overview of nanomechanics; the connections between the luminal surface endothelial glycocalyx and the intra-endothelial cortex, largely composed of actin molecules, is emphasised. The sequelae of endothelial glycocalyx injury include enhanced vascular permeability, tissue oedema, augmented leukocyte adhesion, platelet aggregation, and dysregulated vasodilation. The structure/ function…… Continue reading Glycocalyx Special Edition