Nanobubbles

My Christmas Blog 2021 looks at the fluid physiology of nanobubbles. Clinicians are comfortable with solution of gas molecules in aqueous solutions. We measure the partial pressures of vital gases in blood very frequently, and understand that greater pressure means more molecules (of O2, CO2 etc) per unit volume. We can draw diagrams of O2…… Continue reading Nanobubbles

The Biological/Physical Sciences Divide, and the Age of Unreason

This week I received an email from friend & colleague William (Bill) Muir in the USA. He shared some papers for me to comment on, and they have led me through some very interesting observations about the current state of sciences and their divergence. Time was that medicine and physiology were one and the same;…… Continue reading The Biological/Physical Sciences Divide, and the Age of Unreason

check out @thomaswoodcock and https://fluidphysiology.org for more info. I just make his stuff understandable for mere mortals like me

Every now and then, usually when a Renewal bill arrives, I wonder whether it is worth renewing and maybe I should let this web page pass away with dignity. I started teaching the obvious absurdities of biophysical colloid osmotic pressure manipulations (‘therapies’ except that they don’t actually treat anything) about 2010. Then I had my…… Continue reading check out @thomaswoodcock and https://fluidphysiology.org for more info. I just make his stuff understandable for mere mortals like me

Misconceptions about the Starling principle as applied to fluid therapy.

The recent publication by Löffel et al1 concerning the Starling principle reveals some important misunderstandings common amongst clinicians about the science. The Authors confuse the Frank Starling Law (of the heart) with Starling’s principle of fluid exchange, often expressed as the Starling equation which I explain here. Jv is the transendothelial solvent filtration rate, A…… Continue reading Misconceptions about the Starling principle as applied to fluid therapy.

A big Thankyou to purchasers of the Textbook of Fluid Physiology…

I’m delighted to hear from the Publisher that sales of Fluid Physiology in hardback continue to be strong, and that they feel confident to expand our readership by offering a paperback version at a more affordable price. My hope is that this will enable every prescriber of fluid therapy to have their own copy, or…… Continue reading A big Thankyou to purchasers of the Textbook of Fluid Physiology…

Medical Education in a post pandemic world

The traditional paradigm of lecture theatre gatherings, authoritative Textbooks, accredited congresses and conferences has rapidly dwindled. Today people are choosing Twitter Experts, non-peer reviewed electronic publications, and on-line Presentations without live interactions. Love it or loathe it, there is no going back. Fake News communications are increasingly succeeding in getting published in previously reputable journals;…… Continue reading Medical Education in a post pandemic world

Glycocalyx Special Edition

The American Journal of Pathology Special edition opens with an overview of nanomechanics; the connections between the luminal surface endothelial glycocalyx and the intra-endothelial cortex, largely composed of actin molecules, is emphasised. The sequelae of endothelial glycocalyx injury include enhanced vascular permeability, tissue oedema, augmented leukocyte adhesion, platelet aggregation, and dysregulated vasodilation. The structure/ function…… Continue reading Glycocalyx Special Edition