The latest contribution from Olde Engberink in Amsterdam on the emerging story of sodium storage is Open Access; https://doi.org/10.1007/s00467-019-04305-8 Olde Engberink RHG, Selvarajah V, Vogt L. Clinical impact of tissue sodium storage. Pediatr Nephrol. 2019.
And a new diagram for our basic electrolyte physiology teaching for clinicians.
The authors conclude that “Interstitial and ESL sodium storage is a clinically relevant concept that complicates treatments and diagnostics based on the classical two-compartment model but may also provide new possibilities for treatment of common diseases such as hypertension. The current understanding of the impact of (nonosmotic) sodium storage on daily clinical practice is likely to be only a fraction of the impact it actually has.”
You can also learn more about sodium storage in Fluid Physiology (in press).