I guess we’d not argue that there are likely to be differences in the microvascular physiology of men and women. Professor Virginia Huxley is the Director of the United States National Center for Gender Physiology and Professor in the Department of Medical Pharmacology and Physiology, Missouri. In a recent paper she wrote;
“the incidence and progression of human cardiovascular disease, from the macrovasculature to the microvasculature, differs by sex (Zimmerman & Sullivan, 2013). At the macrovascular level, atherosclerosis occurs more often with greater ill effects in males, whereas pulmonary arterial hypertension occurs with higher frequency in females (de Jesus Perez, 2011). Vascular disorders, such as Hypothernar hammer syndrome (Hui‐Chou & McClinton, 2015), occur more frequently in males, whereas up to 80% Raynaud’s disease patients are female (Fraenkel, 2002). The existence of sex differences has resulted in much of the work focussing on the role reproductive sex hormones and few studies have considered the role of EC being XX or XY.”
https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP276048 Amazing work, and not too soon for clinical trial reports to routinely separate male from female data, or more scientifically XX from XY.