Fresh off the press from Lund, Sweden, this interesting investigation. https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2477-7
Sixty four post-surgical patients with normal heart rate and blood pressure were given human albumin solution 5% in a volume equivalent to 25% of their normal plasma volume in case they were hypovolaemic. How did that get past the ethics committee?
The volume of distribution of radio-iodine labelled human serum albumin increased. Heart rate, arterial pressure and venous pressure remained normal.
It made no difference whether the volume expansion was made over 30 minutes or 180 minutes.
Here’s the question; if you were a patient would you consent to participate?